Severe acne is sometimes associated with higher levels of dehydroepiandrosterone sulphate and free testosterone. The accumulated sebum and clogged epithelial cells may rupture through the follicular wall, releasing sebum into the surrounding dermis.
What type of epithelial tissue is affected by acne?
Follicular epidermis (epithelium).
In addition to the exposed epidermis of the integumentary surface, the follicular epithelium also contributes to cutaneous barrier functions. Loss of physical barrier integrity sometimes occurs when the intensity of inflammation reduces the strength of the follicular wall.
What tissues and cells does acne affect?
Acne occurs when the sebaceous glands produce more oil, clogging different parts of skin tissue. The skin is formed by many layers of tissue, containing hair, glands, muscles, sensory receptors and blood vessels.
What layer of skin does acne affect?
Acne is a chronic disorder of the hair follicles and sebaceous glands located in the middle layer of the skin. In acne, the sebaceous glands are clogged, which leads to pimples and cysts.
How does acne affect the function of skin?
Normally as the body sheds skin cells, the keratinocytes rise to the surface of the skin. When someone has acne, the hair, sebum, and keratinocytes stick together inside the pore. This prevents the keratinocytes from shedding and keeps the sebum from reaching the surface of the skin.
How does acne affect the integumentary system?
Development and Effects of Acne
Sebaceous glands become clogged with sebum, a naturally occurring skin oil, and dead skin cells. Bacteria becomes trapped in these clogged follicles, producing pus and inflammation as the immune system attempts to destroy the bacteria.
How does acne affect the endocrine system?
Excess production of hormones, specifically androgens, GH, IGF-1, insulin, CRH, and glucocorticoids, is associated with increased rates of acne development. Acne may be a feature in many endocrine disorders, including polycystic ovary disease, Cushing syndrome, CAH, androgen-secreting tumors, and acromegaly.
What country has the worst acne?
Results: The overall adjusted prevalence of self-reported acne was 57.8% (95% confidence interval 56.9% to 58.7%). The rates per country ranged from 42.2% in Poland to 73.5% in the Czech and Slovak Republics. The prevalence of acne was highest at age 15-17 years and decreased with age.